Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons

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Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons

Chloride regulation affects brain function in many ways, for instance, by dictating the GABAergic reversal potential, and thereby influencing neuronal excitability and spike timing. Consistent with this, there is increasing evidence implicating chloride in a range of neurological conditions. Investigations about these conditions, though, are made difficult by the limited range of tools availabl...

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2016

ISSN: 2041-1723

DOI: 10.1038/ncomms13495